Van de Ven Brace Ends The Toffees' Run at Brand New Stadium
The Dutch defender emerged as the first backline player to net two goals in a English top-flight match for Tottenham since Jan Vertonghen in spring 2013.
At a glance
The Spurs defender nods home twice in opening period
The home side's defender has goal ruled after VAR review
Pape Matar Sarr nets final goal in dying moments
This loss is Everton's first at their new ground
The Tottenham defender found the net on two occasions as Tottenham extended their unbeaten run on the road in the Premier League and delivered the Toffees their first defeat at their new home.
The Toffees were undefeated in their last five matches at their new ground at the dockside location, having departed their historic home behind after more than a century at the end of the previous campaign.
But Tottenham's leader Van de Ven struck on two occasions from corners in the first half to place their impressive record at risk, and they were unable to mount a comeback before the midfielder - assisted by ex-Everton forward Richarlison - headed home a final goal to seal the victory.
Jake O'Brien thought he had levelled the scores a short while after the defender's first goal, glancing a powerful header past the Spurs keeper from an set-piece.
The Portuguese striker, meanwhile, missed a handful of opportunities, while the Italian goalkeeper made a series of fine stops to guarantee Tottenham went five away games unbeaten in the Premier League.
But the video assistant referee intervened, instructing Craig Pawson to check the score on the screen and the official decided that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
The win elevates the manager's team into third place in the division, a handful of points off north London rivals and leaders Arsenal.
The Merseyside club remain 14th and are six points ahead of the relegation zone.
Spurs breakdown: The defender fulfils duties at both ends of the field
After a drab weekday performance in the European competition against Monaco, where they managed a mere attempts on target, the manager opted for Randal Kolo Muani up front instead of former Toffees player Richarlison.
The summer signing was failed to make much of an impact before being substituted for Richarlison after 60 minutes on the field, but it emerged he proved unnecessary in the end.
Centre-back Van de Ven transformed into an offensive threat to be feared.
Spurs' first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball toward the six-yard box for an unmarked Van de Ven to head home.
And the captain - filling in as skipper in the Argentine's absence - notched his next goal in added time as he outjumped the England keeper to head home.
The Dutchman was just as impressive in defence, partnering well with Kevin Danso as the duo handled excellently with the 34 crosses thrown their way by Everton.
Everton analysis: Everton lacking finishing touch
The club's new home had been a fortress, but it seems the freshness may have faded somewhat and fans headed to the gates after Sarr's third for Tottenham.
The end in the team's unbeaten home run won't be a massive worry for the manager, but their striker situation are.
Beto and the other striker - the Toffees' pair of recognised strikers - had netted just one league goal combined before Sunday's outing.
And they were failed to contribute to that miserable record on a damp and dreary evening on Merseyside.
The striker's performance was epitomized when he opted to bicycle-kick a clear chance from near the goal, even with having room and time to reposition for a more conventional shot that would have challenged the keeper.
Barry, as well, was unable to influence the game after coming on for the starter in the 65th minute.
It was not for a shortage of opportunity. The majority of Everton's attacks came through the winger and the forward, who relentlessly delivered threatening crosses into the Spurs penalty area.
What next for both teams?
Everton: Moyes' men travel to the Stadium of Light in the Premier League on Monday, 3 November at 8 PM.
Tottenham: Spurs go to St James' Park on Wednesday, 29 October for their next round League Cup tie against Newcastle.